Linear IgA Dermatosis

Linear IgA Dermatosis (LAD) is a rare autoimmune skin disorder that primarily affects the skin and mucous membranes. It causes the formation of blisters, often appearing in clusters or rings. In LAD, the body’s immune system mistakenly attacks its own tissues. This leads to the production of antibodies called immunoglobulin A (IgA), which deposit along the basement membrane zone of the skin. This abnormal deposition triggers an inflammatory response, resulting in blister formation. Both adults and children can be affected by LAD. While it can occur at any age, it’s more common in two age groups: young children (around 4-5 years old) and adults in their 60s.

SYMPTOMS

Symptoms of LAD include:

Blisters: Clear or bloody blisters, often grouped together or arranged in rings.
Itching: Many people experience itching before the blisters appear.
Mucous membrane involvement: Blisters can also form on the mucous membranes of the mouth, eyes, and genitals.

DIAGNOSIS

Diagnosing LAD often involves a skin biopsy. A small sample of skin is examined under a microscope to look for the characteristic linear deposits of IgA along the basement membrane zone.

TREATMENT

The primary treatment for LAD is medication. Common treatments include:

Dapsone: An antibiotic that helps reduce inflammation.
Sulfonamides: Another type of medication that can help control the disease.
Corticosteroids: These can help reduce inflammation and suppress the immune system.

In some cases, topical treatments like corticosteroids creams or ointments may also be used to manage mild cases. While LAD can be a chronic condition, many people with the disease eventually achieve remission. However, it’s important to consult with a dermatologist for proper diagnosis and treatment.

IPPF https://www.pemphigus.org/
LAD GUIDELINES https://pubmed.ncbi,nlh.gov/38421060

Do you have LAD?

JJP Biologics is developing a new medicine under code name JJP-1212 < EUCT number: 2023-508661-33-00> . It might help people with Linear IgA Dermatosis (LAD), a skin blistering disease.

Before we can give this medicine to patients, we need to do special research studies called clinical trials. These studies help us understand how the medicine works and determine its safety profile.

Your experience with LAD is very important to us. We want to make sure the participation in clinical trials is comfortable for our patients.

If you willing to share your LAD disease story and help us improve the trial, please fill out the form below.

Your feedback will help us create a better medicine for people with LAD.

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