{"id":2218,"date":"2021-05-18T15:15:26","date_gmt":"2021-05-18T15:15:26","guid":{"rendered":"https:\/\/jjpbiologics.wpengine.com\/?page_id=2218"},"modified":"2021-05-18T15:15:27","modified_gmt":"2021-05-18T15:15:27","slug":"solutions5","status":"publish","type":"page","link":"https:\/\/jjpbiologics.com\/pl\/solutions5\/","title":{"rendered":"Solutions #3"},"content":{"rendered":"<p><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"http:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-1024x683.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-1024x683.jpg 1024w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-300x200.jpg 300w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-768x512.jpg 768w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-1536x1024.jpg 1536w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-370x247.jpg 370w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-800x533.jpg 800w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1-390x260.jpg 390w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/04\/R1A3634a1.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\"><\/p>\n<h6>Pipeline<\/h6>\n<h1>Novel biologics portfolio &amp; partnerships<\/h1>\n<p>Obecnie pracujemy nad szeregiem projekt\u00f3w, z kt\u00f3rych najbardziej zaawansowany obejmuje rozw\u00f3j humanizowanego antagonisty receptora CD89. Celem JJP Biologics jest doprowadzenie naszych projekt\u00f3w do etapu, na kt\u00f3rym ich skuteczno\u015b\u0107 potwierdzona zostanie w badaniach klinicznych. Partnerstwo w rozwoju projekt\u00f3w lek\u00f3w biologicznych jest jednym z modeli wsp\u00f3\u0142pracy JJP Biologics z innymi firmami. Aby dowiedzie\u0107 si\u0119 wi\u0119cej, zapraszamy do kontaktu.<\/p>\n<p><!-- \/.sc_title --><\/p>\n<style type=\"text\/css\">.trx_addons_inline_1339651817{color:#000A55 !important}<\/style>\n<h2>Humanizowany antagonista anty-CD89<\/h2>\n<p>Auto-antigen specific IgA antibodies are associated with disease severity in over a dozen of different auto-immune indications and therefore disease-specific IgA antibodies were selected as companion diagnostic for the development of an innovative therapeutic.<\/p>\n<h4>Nowatorskie podej\u015bcie do roli neutrofili w patogenezie chor\u00f3b autoimmunologicznych<\/h4>\n<p>The anti-CD89 (Fc\u03b1RI) program focuses on antagonizing the IgA receptor CD89 for the treatment of IgA-mediated diseases and the prevention of IgA-mediated pathogenic neutrophilic tissue damage. Neutrophils are part of the innate immune system and are the most ignored cell type of the immune system, but play a devastating role in many auto-immune diseases. Our novel approach is unique in both its target and in its therapeutic potential for neutrophilic-driven diseases, in which treatment options are severely lacking. A significant proportion of auto-immune patients who are not responding to TNF inhibitors have high neutrophil involvement in the disease accompanied by high auto-antigen specific IgA responses. Beyond neutrophil CD89 is also expressed on monocytes, macrophages and eosino-phils which upon IgA binding contribute to the inflammatory response that can also be inhibited by the antagonist anti-CD89 antibody.<\/p>\n<p>The candidate antibodies being developed by JJP Biologics can prevent the IgA-mediated activation of the immune system and inhibit the release of chemo-attractive signals and pathogenic molecules, making them unique in their class. Furthermore, as companion diagnostic for patient stratification and personalized medicine, auto-antigen IgA antibodies which in most auto-immune disease are already embedded in daily clinical diagnosis of patients.<\/p>\n<p>Okazuje si\u0119, \u017ce u znacznej cz\u0119\u015bci pacjent\u00f3w cierpi\u0105cych na schorzenia autoimmunologiczne, nie reaguj\u0105cych na inhibitory TNF, neutrofile odgrywaj\u0105 istotn\u0105 rol\u0119 w przebiegu choroby. Reakcjom tym towarzysz\u0105 wysokie poziomy przeciwcia\u0142 klasy IgA specyficznych dla autoantygen\u00f3w.\nPrzeciwcia\u0142o b\u0119d\u0105ce antagonist\u0105 CD89, opracowywane przez JJP Biologics, zapobiega aktywacji uk\u0142adu odporno\u015bciowego zwi\u0105zanej z IgA oraz hamuje uwalnianie prozapalnych czynnik\u00f3w chemotaktycznych. Mechanizm ten czyni je zdecydowanie wyj\u0105tkowym produktem w segmencie terapeutycznych przeciwcia\u0142 monoklonalnych. Warto zwr\u00f3ci\u0107 uwag\u0119 r\u00f3wnie\u017c na to, \u017ce diagnostyka towarzysz\u0105ca zwi\u0105zana z identyfikacj\u0105 IgA specyficznych dla autoantygen\u00f3w ju\u017c teraz stanowi element codziennej diagnostyki klinicznej pacjent\u00f3w.\n\nPodmioty zainteresowane kupnem licencji na wytwarzanie terapeutycznego przeciwcia\u0142a monoklonalnego o dzia\u0142aniu antagonistycznym w stosunku do CD89 zapraszamy do kontaktu.<\/p>\n<h2>Undisclosed immuno-oncology antibody<\/h2>\n<p>The level of PD-L1 expression on tumours is being used as companion diagnostic to select patients for the treatment with the highly successful anti-PD1 antibodies. In analogy with the PD-L1-PD1 axis, we have selected another checkpoint inhibitor receptor expressed on various tumours and for which the level of expression highly correlates to poor prognosis and therefore is selected to serve as companion diagnostic for the current program.<\/p>\n<h4>Nowatorskie podej\u015bcie do roli neutrofili w patogenezie chor\u00f3b autoimmunologicznych<\/h4>\n<p>Our validated expertise in immunotherapy prompted the discovery and generation of innovative antibodies to new checkpoint inhibitor targets. This target was selected because of its high tumour expression, accompanied by a poor prognosis and immune suppressive tumour microenvironment. Similar to the PD1-PD-L1 axis, tumour expression of our novel target can be used as companion diagnostic for a personalized medicine strategy. This highly selective molecule blocks the regulatory interactions of the target with the patient\u2019s immune system, while leaving Its stimulatory capacity untouched.<\/p>\n<h2>Pipeline<\/h2>\n<p>We also have a range of other undisclosed biologics in development.<\/p>\n<p><img decoding=\"async\" width=\"1635\" height=\"665\" src=\"http:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline.png\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline.png 1635w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-300x122.png 300w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-1024x416.png 1024w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-768x312.png 768w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-1536x625.png 1536w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-370x150.png 370w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-800x325.png 800w, https:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/JJPPipeline-390x159.png 390w\" sizes=\"auto, (max-width: 1635px) 100vw, 1635px\"><br \/>\n<img decoding=\"async\" width=\"570\" height=\"446\" src=\"http:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/shutterstock_389524267-570x446.jpg\" alt=\"\" loading=\"lazy\"><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution\/\" aria-hidden=\"true\"><\/a><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/category\/news\/\" rel=\"category tag\">News<\/a><br \/>\n<!-- .post_meta --><\/p>\n<h5><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution\/\" rel=\"bookmark\">Longitudinal antibody repertoire in \u201cmild\u201d versus \u201csevere\u201d COVID-19 patients reveals immune markers associated with disease severity and resolution<\/a><\/h5>\n<p><!-- .entry-header --><\/p>\n<p>High IgA responses to the virus in severe patients and affinity matured IgG antibodies in mild patients. The viral surface\u2026<\/p>\n<p><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution\/\">Read more<\/a><!-- .sc_blogger_item_excerpt --><!-- .entry-content --><!-- .sc_blogger_item --><img decoding=\"async\" width=\"570\" height=\"446\" src=\"http:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/shutterstock_339727163-570x446.jpg\" alt=\"\" loading=\"lazy\"><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2\/\" aria-hidden=\"true\"><\/a><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/category\/news\/\" rel=\"category tag\">News<\/a><br \/>\n<!-- .post_meta --><\/p>\n<h5><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2\/\" rel=\"bookmark\">IgA mediated pathology after COVID-19<\/a><\/h5>\n<p><!-- .entry-header --><\/p>\n<p>Another example of IgA mediated pathology after COVID-19 infection. Hopefully for the patient this was a transient increase in specific\u2026<\/p>\n<p><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2\/\">Read more<\/a><!-- .sc_blogger_item_excerpt --><!-- .entry-content --><!-- .sc_blogger_item --><img decoding=\"async\" width=\"570\" height=\"425\" src=\"http:\/\/jjpbiologics.wpengine.com\/wp-content\/uploads\/2021\/03\/shutterstock_222655999-e1616107634293.jpg\" alt=\"\" loading=\"lazy\"><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2-2\/\" aria-hidden=\"true\"><\/a><br \/>\n<a href=\"http:\/\/jjpbiologics.wpengine.com\/category\/news\/\" rel=\"category tag\">News<\/a><br \/>\n<!-- .post_meta --><\/p>\n<h5><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2-2\/\" rel=\"bookmark\">High S1-specific IgA antibody levels discriminate severely ill SARS-CoV-2 patients<\/a><\/h5>\n<p><!-- .entry-header --><\/p>\n<p>High S1-specific IgA antibody levels discriminate severely ill SARS-CoV-2 patients. The virus acts as high avidity matrix for neutrophils to\u2026<\/p>\n<p><a href=\"http:\/\/jjpbiologics.wpengine.com\/longitudinal-antibody-repertoire-in-mild-versus-severe-covid-19-patients-reveals-immune-markers-associated-with-disease-severity-and-resolution-2-2\/\">Read more<\/a><!-- .sc_blogger_item_excerpt --><!-- .entry-content --><!-- .sc_blogger_item --><\/p>\n<h6>Subskrybuj<\/h6>\n<h2>Subskrybuj<br \/>\nOtrzymuj naj\u015bwie\u017csze informacje<\/h2>\n<p>Some description text for this item<\/p>\n<p><!-- \/.sc_title --><br \/>\n<script>(function() {\n\twindow.mc4wp = window.mc4wp || {\n\t\tlisteners: [],\n\t\tforms: {\n\t\t\ton: function(evt, cb) {\n\t\t\t\twindow.mc4wp.listeners.push(\n\t\t\t\t\t{\n\t\t\t\t\t\tevent   : evt,\n\t\t\t\t\t\tcallback: cb\n\t\t\t\t\t}\n\t\t\t\t);\n\t\t\t}\n\t\t}\n\t}\n})();\n<\/script><!-- Mailchimp for WordPress v4.9.10 - https:\/\/wordpress.org\/plugins\/mailchimp-for-wp\/ --><form id=\"mc4wp-form-1\" class=\"mc4wp-form mc4wp-form-809\" method=\"post\" data-id=\"809\" data-name=\"Main Form\" action=\"\" ><div class=\"mc4wp-form-fields\"><div class=\"mc4wp-form-fields_wrapper\">\t\r\n\t<input type=\"email\" name=\"EMAIL\" placeholder=\"Adres email\" required \/>\r\n\t<input type=\"submit\" value=\"Subskrybuj\" \/>\r\n<\/div>\r\n<input id=\"mcwp_agree\" name=\"AGREE_TO_TERMS\" value=\"1\" required=\"\" type=\"checkbox\"><label for=\"mcwp_agree\">Wyra\u017cam zgod\u0119 na gromadzenie i przechowywanie przes\u0142anych przeze mnie danych.<\/a><\/label>\r\n<\/div><label style=\"display: none !important;\">Leave this field empty if you're human: <input type=\"text\" name=\"_mc4wp_honeypot\" value=\"\" tabindex=\"-1\" autocomplete=\"off\" \/><\/label><input type=\"hidden\" name=\"_mc4wp_timestamp\" value=\"1776591052\" \/><input type=\"hidden\" name=\"_mc4wp_form_id\" value=\"809\" \/><input type=\"hidden\" name=\"_mc4wp_form_element_id\" value=\"mc4wp-form-1\" \/><div class=\"mc4wp-response\"><\/div><input type=\"hidden\" name=\"trp-form-language\" value=\"pl\"\/><\/form><!-- \/ Mailchimp for WordPress Plugin --><\/p>","protected":false},"excerpt":{"rendered":"<p>Pipeline Novel biologics portfolio &amp; 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